The in vitro antioxidant activity of extracts of Coccinia grandis fruits and leaves has been investigated by DPPH (1, 1-Diphenyl, 2-picryl-hydrazyl) free radical and superoxide scavenging activity (NBT). The aqueous extract of Coccinia grandis fruits and leaves showed significant antioxidant activity by inhibiting DPPH and superoxide radical when compared with methanolic extract. Free radical scavenging activity might be due to presence of flavonoid. The aqueous extract of fruits exhibited potent antioxidant activity with low IC50 values in these two methods. These finding could justify the inclusion of this plant in the management of various disorders in traditional medicine.
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